Arcoxia tablets appeared on the pharmaceutical market not so long ago, however, they are already in quite high demand now. This drug is already actively used in the therapeutic treatment of various diseases of the joints and intraarticular tissues, which are often accompanied by degenerative changes and dystrophic disorders.
Material Content:
- 1 Description of the release form and composition
- 2 Pharmacological action, pharmacodynamics and pharmacokinetics
- 3 What helps tablets Arkoksia
- 4 Instructions for use and dosage
- 5 During pregnancy and lactation
- 6 Alcohol compatibility
- 7 Drug interaction
- 8 Contraindications, side effects and overdose
- 9 Analogues of anesthetic
Description of the release form and composition
Arcoxia is a second-generation advanced COX-2 inhibitor. The main active compound in this drug is etoricoxib.
Depending on the purpose of use, the pharmaceutical company produces the medicine in tablet form with various dosages:
- 60 mg tablets (green);
- 90 mg tablets (white);
- 120 mg tablets (dark green).
And also in the component composition there are a number of additional compounds: lactose, magnesium stearate, titanium dioxide. Tablets are dispensed in cardboard packs and blisters, protected by a film coating.
Pharmacological action, pharmacodynamics and pharmacokinetics
This therapeutic medication belongs to the group of non-steroidal anti-inflammatory drugs that have a pronounced analgesic effect. At the same time, the modern tool is characterized by the most positive safety profile. Arcoxia has anti-inflammatory, analgesic and antipyretic effects. The active composition of the drug stops the spread of substances that cause pain and inflammation.
After internal administration of painkillers, 100% bioavailability of the drug is noted. The maximum concentration of the main active compound is observed one hour after application. Eating does not affect the absorption of a medicinal medication. Excretion is carried out through the kidneys and intestines.
What helps tablets Arkoksia
This medication is prescribed, as a rule, to eliminate unpleasant symptoms that are caused by pain, as well as fever.
Therefore, Arcoxia tablets help in such cases:
- Rheumatoid arthritis, polyarthritis.
- Acute gout.
- Osteoarthrosis.
- Inflammatory and dystrophic pathology of the musculoskeletal system and back.
- Pain in acute gouty arthritis.
And also, sometimes the drug can be prescribed for the temporary relief of severe pain after dental procedures.
Instructions for use and dosage
Determination of the required dosage occurs on an individual basis as directed by a specialist. The standard amount of this medication is one tablet per day, and the duration of therapeutic treatment is not more than ten days.
The required dose is determined on the basis of the patient's history and questioning:
- with osteoarthrosis, 60 mg is prescribed, however, due to the pain syndrome, the amount of the drug may increase;
- patients with rheumatoid arthritis are recommended to take Arcoxia 90 mg tablets;
- for relief of pain discomfort, as well as for acute gouty gouty arthritis, patients should take 120 mg of the drug;
- in the case of painful sensations of a chronic course, 60 mg will be required.
With functional disorders of the cardiovascular system, patients are prescribed the shortest possible courses of therapy, which reduce the likelihood of adverse reactions.
During pregnancy and lactation
According to the instructions for use, Arcoxia is not prescribed for pregnant women. This limitation is due to the lack of clinical studies that could confirm the complete safety of the drug. According to the results of clinical trials in animals, toxic effects on the fetus and reproductive system were revealed. However, the potential harm from its use during pregnancy remains unknown.
As well as Arkoxia tablets are contraindicated during pregnancy due to the fact that during the last trimester the suppression of uterine contractility and premature closure of the ductus arteriosus are not excluded. In addition, there are no results of clinical trials that would confirm the release of the active substance Arkoksia along with breast milk. Based on this, therapy with this drug involves the cessation of lactation.
Alcohol compatibility
The compatibility of this drug with drinks that contain ethanol is rated as unsafe. Based on this, Arkoxia tablets are not recommended to be taken with alcoholic beverages. This is due to the fact that the combination with non-steroidal anti-inflammatory drugs makes them more toxic. As a result, the risk of developing severe adverse reactions is significantly increased, and the liver is also exposed to increased stress.
Drug interaction
According to the official instructions for use, Arcoxia may not be combined with certain drugs.
Therefore, before starting therapy, you should inform your doctor about other therapeutic agents:
- The simultaneous use of cyclosporin or tacrolimus with the described medicinal product significantly increases the risk of developing neuroticity.
- When used in conjunction with methotrexate, its unwanted reactions increase.
- Simultaneous administration with ASA even in small doses can cause ulcerative lesions of the gastrointestinal tract.
- Combined use of Arkoxia with antacids and ketoconazole is allowed.
- With the simultaneous use of Arcoxia tablets with a dosage of 120 mg and oral contraceptives, the risk of thromboembolic disorder significantly increases.
- This therapeutic medication is prescribed with caution to patients who take other medications from the group of anti-inflammatory drugs. This is especially true for acetylsalicylic acid.
- And also requires careful monitoring of patients who are already undergoing a therapeutic course with warfarin or other oral anticoagulants.
- Arcoxia inhibits the elimination of lithium by the renal system, resulting in an increase in its concentration in blood plasma.
- The use of this drug with digoxin is allowed. But this requires control of the toxic effects of the latter.
- When used concomitantly with rifampicin, the concentration of Arcoxia in the blood plasma is significantly reduced. This interaction can cause relapse.
And also there are a number of other conditions in which patients require close monitoring and periodic laboratory blood tests.
Contraindications, side effects and overdose
Before starting therapy with this drug, you should consult a specialist.
Arkoxia medicine has a number of contraindications, in which the use of tablets can harm health:
- peptic ulcer of the stomach during an exacerbation;
- bleeding in the gastrointestinal tract;
- severe functional impairment of the liver;
- severe renal failure;
- serious vascular disorders;
- inflammatory bowel disease;
- heart failure chronic course;
- arterial hypertension;
- cerebrovascular lesions;
- pregnancy;
- age up to 16 years;
- with a deficiency of lactase, lactose intolerance;
- inadequate response of the immune system in the form of an allergy to certain components.
Against the background of contraindications or due to an individual reaction of the body, the likelihood of developing undesirable reactions is not excluded.
Side effects include the following disorders:
- Migraines, dizziness, depression, drowsiness, tinnitus. Often there is anxiety, panic attacks, depression. Hallucinations are extremely rare.
- Changes in taste, visual impairment, conjunctivitis.
- Attacks of palpitations, increased blood pressure, functional disorders of the heart, hypertensive crisis.
- Significant decrease in platelet and white blood cell counts.
- Respiratory manifestations, which include cough, severe shortness of breath, bronchospasm, infection of the respiratory system.
- Digestive disorders associated with bouts of nausea, vomiting, diarrhea and flatulence. Pain in the stomach, indigestion, dry mouth.
- Functional impairment of the kidneys, infections of the genitourinary system.
- Skin manifestations associated with allergic reactions. Swelling, weight gain.
At a standard dosage and therapy for a month, as a rule, there were no signs of an overdose. However, in case of a significant excess of the specified dose, the risk of manifestation of negative reactions from the digestion increases. In this case, removal of the drug from the digestive tract and maintenance treatment will be required.
Analogues of anesthetic
Unfortunately, there are no structural analogues of Arcoxia tablets on the pharmaceutical market. However, it is possible to distinguish some drugs that are synonymous with pharmacological effects, and also have in their component composition the active substance from the NSAID group. These medicines include the following analogues: Dilax, Celebrex, Dynastat, Don, Rumalon, Nimesan, Piroxicam. The replacement of the drug should be agreed with your doctor.
