The pharmaceutical preparation under discussion has a strong antipyretic, pronounced analgesic and anti-inflammatory effects. Candles for children "Nurofen" are used for symptomatic therapy. The medicine eliminates the symptoms of inflammation, but its use does not cancel antibiotic or other medication (if necessary).
Material Content:
The composition of the drug
Nurofen suppositories for the treatment of children are available in two dosages - 60 or 125 mg of ibuprofen. Both drugs are used rectally and can be prescribed to patients of different age groups.
The composition of "Nurofen" in the form of candles, in addition to ibuprofen, includes two types of solid fat. The filler facilitates the introduction of the drug into the anus, the release of the drug, its absorption into the mucosa.
Candles have a torpedo shape, white color, smooth, greasy to the touch surface. Suppositories are packaged in aluminum foil blisters of 5 pcs. Each and are easy to remove. If necessary, the suppository can be cut into two halves with a sharp knife. In one cardboard package there are two blisters, in total - 10 candles.
Pharmacological action and pharmacokinetics
"Nurofen" refers to the group of non-steroidal anti-inflammatory drugs (NSAIDs). The effects of the active substance are based on the ability to inhibit cyclooxygenase enzymes. Ibuprofen reduces the release of endogenous intermediary substances (prostaglandins) involved in the development of the inflammatory process, the appearance of pain.
Suppositories "Nurofen" inhibit the development of inflammation, reduce the pain associated with it.
Advantages of Nurofen suppositories with a children's dosage of the active ingredient:
- triple spectrum of action (analgesic, antipyretic, anti-inflammatory);
- rapid onset, prolonged preservation of the therapeutic effect;
- can be used in patients for whom it is impossible to give syrup or tablets due to young age, dysphagia, vomiting, or for another reason;
- the dose is suitable for the treatment of infants and babies older than 1 year;
- more pronounced analgesic effect compared with paracetamol;
- wide therapeutic range;
- low risk of intoxication;
- good tolerance.
Within 15 minutes after rectal administration of the suppository, the drug is almost completely adsorbed. The active ingredient firmly binds to plasma proteins, enters the inflamed tissue.
The drug begins to act after 20 - 30 minutes: reduces the temperature, eliminates pain.
The medicine reaches its peak concentration within 1 hour 25 minutes. after administration. In total, the effect of the drug lasts from 6 to 8 hours. Metabolism occurs in the liver, where ibuprofen breaks down into two metabolites. Exchange products and a small amount of unchanged medication are excreted through the kidneys.
Age restrictions
Suppositories containing 0.6 g of active substance are intended for infants from 3 months and babies up to two years. A dosage form with 0.125 g of ibuprofen is used to treat small patients 2-6 years old. For those over 6 years old, a suspension is recommended that is produced and marketed under the same brand name.
What helps Nurofen candles for children
Rectal suppositories with ibuprofen are used for short-term (1 - 5 days), symptomatic treatment of fever, pain of mild or moderate intensity. The drug is prescribed to quickly reduce high body temperature, as an anti-inflammatory agent.
In what cases are Nurofen suppositories used:
- fever in childhood infectious and inflammatory diseases, including colds, SARS, flu;
- teething in a child, accompanied by fever and pain in the oral cavity;
- pains of various localization (tooth, head, ear, muscular-articular);
- vaccine response;
- neuralgia.
The instructions for use indicate that "Nurofen" is used as an antipyretic agent for no more than 3 days. The medicine is used to rid the child of pain for no longer than 5 days. If there is no improvement in the condition of a small patient, then an analogue of Nurofen is prescribed. In addition to symptomatic therapy, treatment is carried out with drugs of other groups that eliminate the cause of pain and heat.
Instructions for use
The dosage of the drug depends on the age and body weight of the patient.
- For the treatment of infants from 3 months to 2 years, it is recommended to use Nurofen 60 mg suppositories.
- Children from 3 to 9 months weighing about 6 - 8 kg are given 1 suppository with this dosage every 6 to 8 hours.
The maximum single dose of ibuprofen should not exceed 10 mg / kg body weight.
The daily dose of the drug for a child under 9 months is 180 mg of ibuprofen (no more than 3 suppositories within 24 hours).
For the treatment of fever and pain in children from 9 to 24 months with a body weight of approximately 8 - 12.5 kg, Nurofen 60 mg suppositories are also used. The total daily dose of ibuprofen at the indicated age is 240 mg. This amount of medicine is shared by 4 applications (no more than 4 suppositories in 24 hours).
Suppositories for lowering temperature and (or) reducing pain, for example, when teething, are used with an interval of at least 6 hours.
The total daily dose of ibuprofen in the form of suppositories "Nurofen" 125 mg for children over 2 years of age is from 20 to 30 mg / kg of body weight. For example, a child with a body weight of 15 kg is administered 2 to 3 of these suppositories with an interval of 6 to 8 hours.
- For the treatment of children from 2 to 4 years old with a weight of 12.5 - 17 kg, no more than 3 suppositories of 125 mg / day are used with an interval of 6 to 8 hours.
- Preschoolers aged 4 to 6 years with a body weight of 17 - 20.5 kg are administered no more than 4 suppositories within 24 hours with an interval of at least 6 hours.
Candles are carefully removed with clean hands from the blister pack, slightly warmed in warm water. Enter into the anus and easily push deeper into the rectum. It is recommended that the child first empty the intestines.
If the symptoms in an infant of 3 to 5 months persist or worsen within 24 hours, then seek medical attention. When the temperature and (or) pain in a child older than 6 months do not pass for more than 3 days or his condition worsens, you should also consult a doctor.
The medicine can not be used for more than 4 days without consulting a pediatrician.
Drug interaction
- Other NSAIDs, anticoagulants, lithium preparations, methotrexate, glucocorticoids, enhance the side effects of Nurofen.
- With the simultaneous use of the drug with acetylsalicylic acid, other NSAIDs, there is a risk of liver damage, bleeding and the appearance of gastrointestinal ulcers.
- When used together with tacrolimus and cyclosporine, there is a high risk of kidney damage.
- "Nurofen" can enhance the effect of acetylsalicylic acid, phenytoin (drugs for epilepsy), quinolone antibiotics.
- Diuretics are used to soften the side effects of ibuprofen.
Contraindications, side effects and overdose
"Nurofen" in the form of rectal suppositories is not used for hypersensitivity to ingredients, peptic ulcer, active bleeding.
Children's antipyretic drug with ibuprofen is contraindicated in the following conditions:
- allergies to acetylsalicylic acid, NSAIDs with a similar effect;
- severe hepatic, as well as renal and (or) heart failure;
- bronchospasm, aspirin asthma;
- impaired blood formation.
Among the side effects of the remedy, heartburn, nausea, pain in the upper abdomen and in the liver area are more often mentioned. Blisters may appear on the body, itching, wheezing, shortness of breath, local swelling. Other symptoms are less common: vomiting of blood, flatulence, constipation or diarrhea, darkening of the stool. Unexplained fatigue, headache, irritability, sleep disturbances, blurred vision occasionally occur. In each of these cases, you should stop using the medicine and consult a doctor.
An overdose is usually manifested by the same symptoms as with a side effect, only more intense. In addition, dizziness, drowsiness, involuntary eye movements, ringing in the ears may occur. If blood pressure drops, then the risk of seizures, respiratory depression, coma increases.
If you experience such symptoms, you should immediately seek medical help.
Antipyretic analogues
In Russia, Ibuprofen children’s release in the form of rectal suppositories. Domestic product is a generic "Nurofen" for children, also contains 60 mg of the active ingredient. The cost of a Russian-made drug is from 60 to 85 rubles (imported - more than 100 rubles).
Nurofen is still available in liquid form. A suspension for oral administration - an analogue of the active substance - is prescribed to children from 3 months. Nurofen in the form of 200 mg tablets - for children over 6 years old.
Produce drugs under other trade names in the form of a suspension with ibuprofen (age limit):
- Children's "Maksikold" (3 months).
- "Ibuprofen-Akrikhin" (6 months).
- Children's Advil (3 months).
- "Ibufen" (6 months).
There are many analogues for children in the pharmacological action and form of release. These are suppositories "Paracetamol" (50 and 100 mg), "Cefecon D", "Children's Panadol", "Children's Efferalgan." They quickly eliminate heat, but the effect lasts only 2 to 4 hours.
Children older than 3 months are often prescribed Nurofen when treating colds and other infectious diseases. Candles for children have an antipyretic effect for 6 to 8 hours, which is very convenient for use at night.
