Nurofen Plus is a combination drug that combines several actions. The drug is sold in the form of elongated white tablets. You can buy a medicine from a pharmacy network according to a doctor’s prescription.
Material Content:
The composition of the drug
Nurofen Plus, the composition of which has 2 active components in the form of ibuprofen and codeine, includes several additional ingredients:
- corn starch;
- microcrystalline cellulose;
- sodium starch glycolate;
- talc;
- hypromellose;
- titanium dioxide;
- purified water;
- denatured ethyl alcohol.
Excipients have little effect on the body, but can cause the development of negative manifestations, for example, an allergic reaction.
Pharmacological action and pharmacokinetics
Nurofen Plus tablets have anti-inflammatory, antipyretic, antitussive and analgesic effects. A similar effect on the body is achieved due to the active components.
Codeine, which has an antitussive effect, suppresses the activity of potassium receptors, and in combination with ibuprofen, enhances its analgesic effect.
Ibuprofen blocks cyclooxygenase enzymes, inhibiting prostaglandin synthesis.
After taking the medication, it is rapidly absorbed from the gastrointestinal tract and is 90% bound to blood plasma. The maximum concentration of the drug in the body is observed after 45 minutes.When using the product along with food, the absorption rate may be reduced by 2-3 times.
The active substances slowly penetrate into the tissues of the joints, but accumulate there in a greater concentration than in the blood.
Drug metabolism occurs in the liver. Decay products and unchanged particles (1%) of the drug are excreted in the bile and urine. The half-life of ibuprofen is 2 hours.
Codeine is absorbed into the blood from the gastrointestinal tract by 30%. The highest concentration reaches 60 minutes after taking the tablets. It is excreted through the urinary system. The half-life is 3-4 hours.
What helps Nurofen Plus
The anti-inflammatory drug "Nurofen Plus" is indicated for use in cases where a medication with one active substance did not give the desired result.
Indications for use:
- pain in the head area;
- migraine;
- toothache;
- neuralgic pains;
- pain in the back;
- dysmenorrhea;
- muscle pain;
- rheumatic pain.
Before using an opioid analgesic, you should consult a specialist and carefully study the instructions.
Instructions for use and dosage of tablets
Nurofen Plus at a concentration of 200 mg + 10 mg must be taken orally with a large volume of liquid.
The medication in question is not intended for long-term therapy. The maximum period of use of the tablets is 3 days.
If short-term therapy does not produce results, you need to visit a specialist to change treatment tactics.
The medication is allowed for admission to people over 12 years old. The recommended dose is 1 tablet up to 4 times in 24 hours. The minimum interval between the use of the drug is 4 hours. A single dose for persons over 18 years of age can be increased to 2 tablets.
The maximum daily dosage for adolescents is 1000 mg, for adults - 1200 mg.
During pregnancy and breastfeeding
The instruction for use states that the use of a pharmacological agent during breastfeeding and pregnancy is strictly prohibited.
Drug interaction
Experts do not recommend combining the use of the pharmacological agent in question with acetylsalicylic acid and other non-steroidal anti-inflammatory drugs.
The simultaneous use of Nurofen with acetylsalicylic acid leads to a decrease in the therapeutic effect of the second drug. People taking salicylic acid to prevent blood clots are at risk of developing acute coronary insufficiency.
Using the Nurofen Plus medication at the same time as medicines that reduce the rate of blood coagulation increases the risk of bleeding.
The use of a non-steroidal anti-inflammatory drug in combination with Citalopram, Fluoxetine, Paroxetine and Sertraline increases the risk of serious gastrointestinal bleeding.
NSAIDs in combination with the following drugs creates the likelihood of hemorrhagic syndrome:
- "Cefamandol";
- "Cefoperazone";
- Cefotetan;
- "Valproic acid";
- Plikamycin.
Ibuprofen in combination with medications containing gold leads to the development of renal pathologies.
Codeine in combination with hydroxyzine leads to a more pronounced analgesic and sedative effect, and also contributes to inhibition of the central nervous system.
"Nurofen Plus" significantly enhances the action of diuretic pharmacological agents. Perhaps the development of dehydration.
With the simultaneous use of the medication in question and Quinidine, the analgesic properties of the drug presented are suppressed.
Alcohol compatibility
Prescription drug "Nurofen Plus" is not recommended to drink before drinking alcohol and directly under the influence of alcohol.
Codeine when interacting with alcoholic beverages leads to marked inhibition of the central nervous system.
Contraindications, side effects and overdose
The use of an analgesic is prohibited in the following conditions:
- ulcers in the gastrointestinal tract during an exacerbation;
- heart or lung failure;
- increased intracranial pressure;
- a constant increase in blood pressure over 140/90;
- TBI;
- bronchial asthma, urticaria, or rhinitis caused by taking non-steroidal anti-inflammatory drugs;
- pathologies of the optic nerve;
- abnormal urinary system and liver;
- hemophilia;
- low white blood cell count;
- hearing impairment;
- violation of normal bowel movements;
- inability to perceive the components that make up the drug.
With extreme caution, an anti-inflammatory agent should be used for any pathology of the gastrointestinal tract, kidneys and liver, since complications may develop.
Ibuprofen in combination with codeine may be accompanied by the following negative reactions of the body:
- bouts of nausea and vomiting;
- heartburn;
- violation of bowel movements;
- increased gas formation;
- discomfort in the stomach and intestines;
- persistent or periodic pain in the region of internal organs;
- hearing impairment;
- headache;
- inability to fall asleep quickly;
- drowsiness;
- mood swings;
- heart rhythm disturbance and increased blood pressure;
- swelling;
- pathology of the hematopoietic system;
- allergic manifestations;
- impaired respiratory function;
- increased sweating.
Long-term use of a drug in high concentration can lead to impaired visual function, bleeding and the formation of ulcerative lesions on the mucous membranes of the gastrointestinal tract.
When using the medication for 2-3 days, the negative reactions of the body are practically not observed.
The antipyretic agent has a combined composition, therefore, with its excessive use, the toxic effect of the active components is different. The main manifestations are observed from an overdose of codeine.
The half-life of a pharmacological agent with its excessive use is 1.5–3 hours.
Codeine in a dosage of over 500 mg at a time is fatal for an adult.
In children, negative effects are observed with 400 mg of ibuprofen per 1 kg of body weight.
Overdose Signs:
- pain in the intestines and stomach;
- vomiting
- nausea.
After identifying signs of an overdose, a person should be at least 4 hours in a hospital under the supervision of a specialist. To eliminate intoxication, gastric lavage and symptomatic therapy are recommended.
Analogs of Opioid Analgesic
Full analogues of Nurofen Plus today do not exist. If necessary, a specialist can choose a drug with a different composition, but an identical type of action.
Preparations containing ibuprofen:
- Nurofen and Nurofen Express;
- Ibuprofen
- "Ibalgin";
- Gofen;
- Faspik.
The medicines presented are approximately the same in effect as Nurofen Plus, but have a less pronounced effect due to the lack of codeine.
Pharmacological agents based on codeine, similar in indications and effect:
- "Paracodamol";
- Codelmix
- "Panadein."
Despite the large number of products reminiscent of effects on the body, one should not independently choose an analgesic analogue. With the wrong selection of the drug can cause significant harm to the body.
Nurofen Plus effectively helps with headaches and pain in the teeth or back, but it does not eliminate the cause of the discomfort. To completely get rid of the problem, you should visit a specialist and undergo an examination.
