With severe pain syndrome of any etiology, patients try to alleviate the condition during treatment. You can quickly improve your well-being with the help of Nurofen Forte. This drug has an extensive list of indications, which makes it indispensable in any medicine cabinet.

The composition of the drug

Nurofen Forte tablets include 400 mg of ibuprofen as an active ingredient. They are white in color and have a shell on which on one side there is a red marking “Nurofen 400”. In addition to the active substance, the medicine contains supplements: colloidal type silicon dioxide, croscarmellose sodium, citrate and lauryl sulfate, as well as stearic acid.

The drug is packaged in 6 or 12 pcs. on a contour plastic plate, and in a package of thin cardboard are 1-2 such blisters.

There is also Nurofen Ultracap. It is available in capsule form and contains only 200 mg of the active ingredient. But in speed and force of impact, it is not inferior to the previous one. This is due to a higher degree of absorption of the drug in liquid form, which is located inside the shell. Vitamin E, macrogol 600 and povidone K17 are present in the medicine as additional substances. The package contains 1 blister of thin plastic for 4 or 10 pcs.

Nurofen Forte Express capsules have a faster effect.The content of the active substance coincides with that in tablets, but the speed of action is faster due to the liquid contents inside the shell. As additional components, potassium hydroxide, macrogol 600 and water are added to it. They provide the desired dosage form.

Pharmacological action and pharmacokinetics

Nurofen Forte refers to non-steroidal anti-inflammatory drugs that relieve pain symptoms and are able to lower body temperature. The effect is achieved by inhibiting the formation of prostaglandins. These are substances that play the role of inflammatory mediators. The result is achieved by reducing the effect of cyclooxygenase type 1 and 2 on body cells. The active substance of the drug is capable of reversibly inhibiting platelet aggregation.

The medicine is well absorbed in the digestive tract. If you use the drug in the form of tablets on an empty stomach, then its maximum amount in the blood will be in 45 minutes. If the patient previously ate, the time increases to 1-2 hours. When using Nurofen Express Forte in an amount of 2 pcs. the highest concentration of the active component in plasma is observed after 30-40 minutes.

Nurofen Forte is able to block pain for up to 8 hours. Although after 120 minutes. its amount in the blood is halved. Biotransformation of the active component occurs in the liver. Metabolites excreted in the urine and bile.

What helps Nurofen Forte

Since the drug has several actions at once, it is prescribed for pathologies of a different nature.

Nurofen Forte is used for such problems:

  • back pain;
  • migraine-like attacks;
  • SARS and influenza (as an antipyretic);
  • joint pain
  • chills from fever;
  • infection of the upper parts of the respiratory system of an acute nature, unspecified and multiple location;
  • Toothache
  • dysmenorrhea of ​​unknown etiology;
  • pain in the middle of the cycle;
  • polymyalgia of rheumatic origin;
  • headache;
  • inflammation of the nerve or neuralgia;
  • muscle soreness;
  • dorsalgia;
  • pain of unknown origin.

The universality of the drug is expressed not only in a variety of therapeutic effects, but also in a wide list of indications. At the same time, the Nurofen regimen is quite simple. And the variety of dosage forms facilitates the selection of the optimal dosage and time of exposure.

Instructions for use and dosage of tablets and capsules

The medicine is taken orally before meals. But in the presence of gastritis, it is recommended to use the drug with food. Nurofen Forte is not used for course therapy. Treatment cannot last more than 3 days.

Instructions for use Nurofen Forte in capsules and tablets stipulates the same dosage: for patients from 12 years of age, and then prescribe 1 pc. (400 mg of the active ingredient) 3 times a day. The time between two doses of the drug should be more than 6 hours for the tablet form and 4 hours for the capsule. Nurofen Forte can only be used as a temporary measure until you contact a specialist.

During pregnancy and breastfeeding

Nurofen is not recommended for pregnant women in the later stages. In other periods, it can be prescribed for treatment under the supervision of a specialist. Ibuprofen is able to get into a mother’s milk in a small concentration, but it does not have a negative effect on the baby. Therefore, at this time its use is not prohibited.

Drug interaction

Since the drug is part of the NSAID group, it has a powerful systemic effect.

For this reason, it is worth considering the features of its interaction with drugs of other classes:

  • salicylates and other non-steroidal anti-inflammatory drugs increase the chance of manifestation of unwanted symptoms, including acute coronary insufficiency;
  • thrombolytics, hypoglycemic agents for oral administration, insulin and sulfonylurea metabolites, anticoagulants - increase their effect on the body, especially warfarin;
  • diuretics and antihypertensive drugs, including ACE inhibitors, lose their effectiveness, and in the elderly provoke disruption of the excretory system up to acute renal failure;
  • glucocorticosteroids - provoke the occurrence of ulcerative defects and bleeding from the digestive tract;
  • Cyclosporin, Tacrolimus - increase the toxic effect on the kidneys;
  • antiplatelet drugs - increase the risk of bleeding from the digestive tract;
  • methotrexate, lithium-based products - are delayed and accumulate in the body;
  • caffeine - increases the severity of pain relief;
  • cardiac glycosides - provoke the development of heart failure, accumulate in the body and reduce the rate of urine filtration by the glomeruli of the kidneys;
  • Zidovudine, myelotoxic drugs - increases hepatotoxicity, increases the chance of developing hematomas and hemarthrosis in HIV + patients with hemophilia;
  • drugs that suppress microsomal oxidation - reduce the toxic effect on the liver;
  • Mifepristone, uricosuric agents - the severity of their action is reduced (it takes from 8 to 12 days before the first possible use of ibuprofen);
  • antacid preparations - their absorption worsens, the effect decreases;
  • tubule secretion blockers - provide accumulation of the active component of Nurofen;
  • quinolone antibiotics - increase the chance of a convulsive syndrome;
  • microsomal oxidation stimulants, including barbiturates, phenytoin, antidepressants of the tricyclic structure, phenylbutazone, rifampicin - trigger the formation of active metabolites of the hydroxylated form, which provoke serious intoxication;
  • Cefoperazone, valproic acid, cefamandol, plicamycin, cefotetan - increase the chance of a prothrombin deficiency.

Due to the presence of dangerous complications, Nurofen Forte in complex therapy should be prescribed by a doctor. If the patient is taking one of these drugs, he needs to consult a specialist before using drugs from the NSAID group. This will help you choose the optimal dosage to avoid possible consequences.

Alcohol compatibility

Since ibuprofen is metabolized in the liver, and alcohol has a significant negative effect on this organ, taking them at the same time is not recommended. As a result, a large number of hydroxylated metabolites of increased activity can form.

Attention! This will give a high load on the organ and can provoke a violation of its functions, up to the symptoms of severe intoxication.

Therefore, for the period of therapy, it is worth giving up alcohol. So it will be possible to maintain healthy liver and avoid unpleasant consequences.

Contraindications, side effects and overdose

Nurofen Forte has a high concentration of the active substance and a pronounced effect. Therefore, its use imposes certain restrictions.

The drug is not suitable in such conditions:

  • the presence of allergies to one of the components;
  • bleeding from the digestive tract and intracranial hematomas;
  • the presence of cases of allergic reactions to any NSAIDs in the past;
  • an increase in the concentration of potassium in the blood, confirmed by laboratory;
  • carrying a child;
  • exacerbation of pathologies of erosive and ulcerative nature;
  • severe failure of the liver or kidneys;
  • under the age of 12 years;
  • recent heart bypass grafting;
  • pathological coagulation, including hemophilia.

If the patient has a contraindication to the appointment of Nurofen, the medicine can be replaced by another, with a similar effect. In some cases, the appearance of undesirable effects during the period of treatment with the drug is possible.

These include:

  • pathologies of the blood and lymph system: anemia, including aplastic and hemolytic type, a decrease in the number of leukocytes and platelets, the complete absence of granulocytes (manifested by ulcers on the oral mucosa, sore throat, weakness, nosebleeds, subcutaneous hematomas);
  • digestive tract diseases: epigastric pain, flatulence, nausea, heartburn, constipation or diarrhea, vomiting, peptic ulcers, digestive system bleeding, vomiting or feces with blood, intestinal wall perforation, stomach inflammation, ulcerative stomatitis, transition Crohn's disease and ulcerative colitis in the acute phase;
  • immunity disorders: Lyell syndrome, allergic reactions, anaphylaxis, exacerbation of bronchial asthma, angioedema, dyspnea, respiratory failure, bullous and exfoliative dermatoses, bronchospasm, Stevens-Johnson syndrome, vasomotor rhinitis, erythema multiforme type, increase in number heart rate acceleration, drop in blood pressure;
  • liver pathology: jaundice, organ malfunction, an increase in blood transaminases, toxic hepatitis;
  • diseases of the excretory system: acute renal failure in the stage of compensation or decompensation, edema, an increase in the amount of urea in the blood, the detection of protein and blood in the urine, nephritic and nephrotic syndromes, inflammation of the interstitium of the kidneys, papillary necrosis, inflammation of the bladder;
  • disorders of the heart and blood vessels: hypertension, insufficient functioning of the heart, edema of peripheral localization, myocardial infarction;
  • diseases of the nervous system: headaches, inflammation of the meningeal membrane of an aseptic nature;
  • laboratory: a decrease in the amount of hemoglobin or hematocrit, an extension of the term for stopping bleeding, a decrease in creatinine clearance.

The higher the dosage of the drug, the greater the chance of side effects. Most often they occur in older patients. Sometimes patients take too much medicine or do not follow the time interval.

In this case, an overdose occurs, the signs of which include:

  • gagging;
  • bouts of nausea;
  • epigastric pain;
  • diarrhea;
  • sensation of tinnitus;
  • digestive bleeding;
  • headache;
  • fatigue;
  • convulsive syndrome;
  • hyper excitability;
  • loss of orientation in space;
  • coma;
  • metabolic acidosis;
  • hypotension;
  • kidney failure;
  • toxic liver damage;
  • respiratory failure;
  • blue skin.

If there is a suspicion of an overdose of the drug, you should give the person an enterosorbent and call an ambulance. Doctors will perform the necessary manipulations and solve the issue of hospitalization of the patient. It is important to quickly seek medical help, as the condition can threaten the patient's life.

Analogs of NSAIDs

Among non-steroidal anti-inflammatory drugs similar to Nurofen Forte, Mig 400 is isolated. It contains the same active substance in the same concentration as the original drug. It is produced in tablet form and packaged in 10 and 20 pieces. in cardboard boxes.

Equal in effectiveness to Nurofen Forte is considered Faspik. It exists in the form of tablets and granules for dilution with water. The dosage in solid form is 400 mg, and in liquid 200 mg. The active component and application scheme coincide with the original tool.

Nurofen Forte provides quick assistance with pain symptoms of any etiology. But before using it, you should familiarize yourself with the contraindications and its interaction with various drugs. Then the application will bring only relief and will not cause any inconvenience.

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