The pronounced psycho-vegetative effect and the stimulating effect of grandaxin (tofisopam) made the drug a popular daily tranquilizer in Russia. The inability to purchase without a doctor’s prescription, as well as the rather high cost of this drug, make you carefully study the pharmaceutical market in order to find the optimal and safe analogues of grandaxin.
Material Content:
The composition (active substance) of the drug
Grandaxin 50 mg is available in tablet form with the GRANDAX logo. The medicine belongs to anxiolytics; It is considered a small tranquilizer, ataraktik, antiphobic sedative. The term is a derivative of the Latin word anxietas ("anxiety, fear") and the Greek lytikos ("liberating, delivering").
The main active component of this anxiolytic agent is tofisopam, a representative of the benzodiazepine series. The substance was obtained during the chemical transformation of a diazepam molecule.
Having tranquilizing activity, subject to the instructions for use, the substance does not have a concomitant negative effect on the condition and vital activity of a person inherent in this category of drugs:
- does not cause drowsiness;
- does not reduce the tone of skeletal muscles;
- does not affect motor activity;
- does not have an anticonvulsant effect;
- does not provoke a “withdrawal effect” after completing a course of therapy;
- it does not cause drug tolerance of a similar biological structure: cross-habituation is practically excluded.
In one tablet of grandaxin, the concentration of the drug is 50 mg.In addition, the composition of the product includes chemically indifferent substances (lactose monohydrate, starch, cellulose, talc, etc.). Auxiliary components do not have a positive or negative effect on the body. Their properties give the tablet storage stability, make it stable and durable. The most important function of additional ingredients is to ensure accurate dosage of the drug.
List of cheap Russian analogues of Grandaxin
Replacing the drug with a more affordable one should be adequate to the diagnosis and symptoms. Analogues are cheaper not only designed to provide the necessary therapy, but also must be safe, have a minimum of side factors. First of all, do not forget that tofisopam is a daily tranquilizer that does not have sleeping pills and relaxing effect.
Check out the list of domestic drugs that alleviate the typical symptoms in patients taking grandaxin to varying degrees.
Afobazole
Well-known domestic tranquilizer, not addictive and withdrawal. Therapy is aimed at reducing anxiety and anxiety, improving sleep quality, stopping the manifestations of withdrawal symptoms. Facilitates the condition with PMS and menopause. Helps to adapt when quitting smoking, reduces irritability. The medicine is made in tablets.
Valerian extract
A herbal remedy with sedative qualities is able to partially replace Grandaxin. It produces a mild sedative effect. Dosage forms - tincture and tablets.
Melissa officinalis
Natural raw materials from dried lemon mint insist, guided by the manufacturer's recommendations. They drink several times a day with a depressed emotional state, depression and neurosis.
Phenibut
Refers to nootropics. The active substance is aminophenylbutyric acid. The main impact on the state of the brain: normalizes tissue metabolism and vascular tone, improves microcirculation and blood flow. It is a psychostimulant and tranquilizer. Reduces anxiety, reduces anxiety, fear and tension. With a course of treatment improves memory, sleep quality, physical and mental activity.
If the instructions to Grandaksin do not contain direct instructions to restrict driving, then during Phenibut therapy it is better to refuse to drive. The instructions noted that the attention and speed of psychomotor reactions are somewhat reduced. On the shelves of pharmacies you can find Phenibut from Latvian and Belarusian pharmacists.
Imported Drug Substitutes
Below are analogues of grandaxin from foreign manufacturers.
Neurol
The manufacturer of the drug is ZENTIVA (Czech Republic). Derivative of benzodiazepine, tranquilizer. Active anxiolytic, has a sedative, antidepressant and muscle relaxant effect. It treats phobias, neurosis, relieves anxiety and panic states. Unlike Grandaxin, it is better not to take it during the day - the drug has a mild hypnotic effect.
Adaptol
Latvian medicine (manufacturer of JSC Olainfarm). The medicine belongs to the category of daytime tranquilizers: a pronounced calming effect is not accompanied by muscle relaxation and impaired coordination of movements.
Reduces emotional stress, eliminates anxiety, anxiety and fear. Reduces irritability and excessive emotionality without creating a feeling of euphoria. It is not forbidden to operate mechanisms, work at height and drive a car. It also has a nootropic effect. Adaptol activates brain activity: increases logicality and speed of thinking, stimulates mental processes, improves attention and memory.
Valevigran
Ukrainian preparation from natural raw materials (valerian). The extract has a sedative effect, softens nervous excitability, eliminates depressive anxiety symptoms.
Atarax.
A tranquilizer from a Belgian manufacturer is available in the form of tablets or a solution for intramuscular injection. The medication is intended to relieve anxiety states, excessive psychomotor agitation and internal overstrain.
It is prescribed for chronic alcoholism, an adaptation disorder and many diseases of somatic origin. Improves cognitive abilities. Atarax can adversely affect attention and speed of reactions, therefore it is better not to drive during a course of therapy.
Complete Prescription Structural Generics
For several years, such a popular medicine without a prescription is impossible to get. Therefore, there is a need to find a replacement.
The main active ingredient of the drug is tofisopam. Grandaxin has many analogues with a similar therapeutic effect on the body, but the drug does not have an absolute generic with a similar composition.
The only way out is to select a medicine with a similar effect. For example, one of those described in previous chapters. Or a more prudent decision is to visit a doctor and get a prescription. In the event that the specialist considers taking the drug really necessary therapy.
Brief instructions for use
Prescribed Prescription Medication is manufactured in Hungary. 50 mg tablets are sealed in blisters in 10 cells.
It is absorbed into the blood from the stomach very quickly, the concentration reaches a maximum within 120 minutes. Tofisopam does not have the ability to cumulate in the body. Tissues do not accumulate the substance, therefore, the toxic effect of prolonged course therapy is excluded. It is excreted almost completely with urine.
Grandaxin is prescribed for neurosis, depression, cardialgia, mental adaptation deviations after stress, PMS, menopause, chronic alcoholism and the need to stop the acute symptoms of withdrawal symptoms, with diseases and pathologies of muscle tissue (when a pronounced relaxing effect is contraindicated).
It cannot be taken with particular sensitivity to benzodiazepines, in cases of excessive psychomotor irritability, aggressive conditions, decompensation of respiratory failure. Depression in acute or very severe manifestation is also an obstacle to therapy with Grandaxinum. It is forbidden to take it in the first 3 months of pregnancy, during the period of feeding the baby. If the patient is threatened with respiratory arrest during sleep, the medicine is contraindicated.
The dosage should be selected by the attending physician on the basis of the diagnosis and its clinical form, as well as the patient's condition. An adult is usually prescribed 50-100 mg of the drug, which is identical to 1-2 tablets. The maximum daily dose should not exceed 300 mg. The frequency of administration is 1-3 times / day. If the patient has a history of renal failure or old age, the dosage is reduced.
Some people report an undesirable side effect of the drug: problems with appetite and stools, nausea, headache, muscle tension and soreness. Sometimes there is agitation, irritability and insomnia.
The simultaneous administration of tofisopam and certain immunosuppressants should not be allowed. The combination of grandaxin and drugs that depress the central nervous system (anesthetics, sedatives, hypnotics, antihistamines, as well as analgesics and antidepressants), significantly enhances their therapeutic effects, including side effects.
Antifungal drugs, contraceptives, omeprazole and antacids impair the absorption of the active substance, increasing its concentration in the blood. Nicotine, alcohol, on the contrary, activate the metabolism of tofisopam, reducing its concentration in plasma, minimizing the healing properties of the substance. Doctors prohibit the use of grandaxin in chronicles of mental illness, obsessive states, phobias. With therapy, the risk of an aggressive state and suicide increases significantly.
Studies of the drug have proven that patients with liver and kidney pathologies are more likely to experience side effects of the drug. Tofisopam contains lactose, which patients with intolerance to this category of carbohydrates must definitely remember.
Grandaxin does not have a significant negative effect on concentration and attention, therefore, a restriction on driving is not established.
The medicine is stored under standard conditions for no more than 5 years.
