Duphaston is a synthetic analogue of progesterone belonging to the group of progestogens. This hormonal agent is widely used in gynecology. With its help, various pathologies based on hormonal disruptions are treated. Our article details how to take Duphaston.
Material Content:
The composition of the drug
The instructions for use say that Duphaston is produced by the Netherlands pharmaceutical company only in tablet form.
Each tablet contains 10 mg of the active component of dydrogesterone, in addition to which, the drug is enriched with the following auxiliary ingredients:
- cellulose;
- starch;
- silica;
- lactose;
- dye.
Auxiliary components provide better digestibility of the active substance.
pharmachologic effect
Due to its main component, Dufaston 10 mg tablets are similar to the natural progesterone synthesized by the female body. After penetration into the circulatory system, the drug has a similar effect with endogenous hormone. Dydrogesterone does not affect metabolic processes, worsening of blood coagulation, temperature balance. During treatment with Duphaston, fat metabolism is normalized. A medication can normalize cholesterol in the body. Tablets have a positive effect on the endometrium, do not allow an increase in its volume.
The hormonal drug is not a contraceptive, does not affect the onset of ovulation.Menstrual flow goes in the usual way, against the background of its intake there is no cycle change. With Duphaston, pregnancy is possible. The active component does not negatively affect the organisms of women and fetuses.
After penetration into the body, the active substance is rapidly absorbed into the bloodstream, evenly distributed over organs and systems. The metabolic process occurs in the liver, the active component is excreted by the urinary system after 18 hours.
On a note! This hormonal drug is part of the complex therapy for menopause.
Why is the drug prescribed?
Usually Duphaston is prescribed for insufficient production of progesterone, which causes infertility, it happens at the beginning of the menopause. The active substance of the medication allows you to maintain menstrual function. Against the background of taking tablets, metabolic processes are accelerated, depending on the amount of progesterone.
The medicine is used in the following cases:
- endometriosis;
- dysmenorrhea;
- menstrual irregularities;
- ICP;
- amenorrhea;
- with painful periods;
- bleeding from the uterine region;
- ovarian cystosis;
- myoma;
- infertility
- at the beginning of pregnancy, with the threat of miscarriage.
Often, the drug is used to neutralize the increase in endometrial tissue against a background of natural, operational menopause.
Instructions for use Duphaston
The hormonal drug regimen is prescribed individually, based on the pathology, condition of the woman, phase of the menstrual cycle. To obtain the desired result, it does not matter if Duphaston is taken before or after a meal.
- Dufaston with endometriosis is prescribed in a dosage of 10 mg. In this case, it is recommended to drink tablets in the interval between 5-25 days of menstruation, without a break;
- take Duphaston to get pregnant, it is necessary in the interval between 11-25 days of the menstrual cycle. In this case, the hormonal drug is used for a long time - from 3 months to six months;
- with the threat of miscarriage, this hormone is used only after a woman is diagnosed with a lack of progesterone. Usually, 40 mg of Duphaston is prescribed once. Then, 7 days is indicated to drink 10 mg four times a day. Then there is a gradual decrease in the dosage of tablets. With a new threat of miscarriage, the dosage increases again. Sometimes Dufaston therapy lasts up to 20 weeks of pregnancy;
- in premenstrual syndrome, tablets are taken between 11-25 days of the menstrual cycle for six months;
- Duphaston with a delay of menstruation is taken between 11-25 days of the menstrual cycle with a dosage of 20 mg twice a day;
- with amenorrhea, Duphaston is prescribed simultaneously with estrogens. This therapy lasts 3 months. The dosage is prescribed individually;
- with dysfunctional menstruation, it is required to take 10 mg of the drug twice a day for a week in combination with ethinyl estradiol;
- with hyperplasia of the uterine mucosa, therapy is carried out in the interval between 16-25 days of the menstrual cycle;
- with a cyst, the drug is prescribed individually for 3 months.
On a note! The recommended daily dosage is divided into three doses after an equal period of time.
Duphaston during pregnancy is used in the usual dosage, does not require discontinuation of the drug or a decrease in its dose.
During pregnancy and lactation
Perhaps the use of Duphaston during pregnancy. Usually this drug is used to prevent premature birth, miscarriage, to prevent a missed pregnancy. The dosage of a hormonal agent is prescribed individually - after a diagnosis of progesterone levels. During lactation, the appointment is made strictly according to the indications.
Drug interaction
Duphaston is usually well tolerated by patients.This drug is often prescribed at the same time as estrogen, if a woman does not become pregnant for a long time. Concurrent administration of Rifampicin leads to an acceleration of the decay of Duphaston, a decrease in its effectiveness. It is not recommended to use this hormone with a medicinal plant Borovaya uterus. This complex can cause uterine bleeding.
Contraindications, side effects and overdose
Duphaston is contraindicated if the patient has intolerance to the active component. With caution, a medication is prescribed with a predisposition to itching of the skin, dermatitis.
During treatment with this hormonal agent, the development of the following adverse reactions from the body is possible:
- pain in the lower abdomen;
- decreased performance;
- a feeling of heaviness in the right hypochondrium;
- icteric shade of the skin, mucous membranes;
- paroxysmal headache;
- anemia
- bleeding from the uterine cavity;
- breast tenderness;
- itching of the skin;
- puffiness of the skin;
- Quincke's edema;
- lowering blood pressure.
Any manifestation of side effects requires dosage adjustment of the medication. An overdose of Duphaston is manifested by persistent nausea, vomiting. This situation requires gastric lavage. It is also recommended to drink sorbents.
Analogs
Usually, the following drugs are recommended as analogues of Dufaston:
- Prajisana;
- Utrozhestan;
- Dydrogesterone;
- Iprozhina.
The choice of Duphaston analogues should be carried out exclusively by a doctor, since hormone therapy is prescribed in strict accordance with the diagnosis.
Duphaston is a modern medication that is a complete analogue of the female hormone used to treat many diseases when planning a long-awaited pregnancy.
