Amoxiclav 875 mg + 125 mg: instructions for use by adults and children, tablet composition, dosage, antibiotic analogues

With the advent of winter, therapists have more work to do. Frosts, lack of vitamins and sunlight affect not only the mood, but also on the health status of the population as a whole. In the cold season, infections lie in wait for us everywhere. If the disease is bacterial in nature, the doctor will prescribe an antibiotic. Amoxiclav 875 + 125 mg is used in the treatment of bronchitis, tonsillitis, otitis media, pyelonephritis, cystitis and other seasonal diseases.

The composition of the drug

This medication has a combined composition, including amoxicillin and clavulanic acid. Aminobenzyl penicillin was originally bred by combining chemical components using natural material. It is the most commonly prescribed antimicrobial drug.

This tool copes with microorganisms of different types:

• intracellular parasite listeria;
• gram-positive microorganism streptococcus;
• enterobacteria;
• opportunistic staph bacteria;
• spiral bacterium that lives in the pylorus of the stomach;
• facultative anaerobic genus proteus;
• the causative agent of dysentery shigella;
• obligate aerobic gonococcus;
• gram-negative bacterium meningococcus.

Clavulanic acid in the composition of the drug slows down the production of complex protein molecules in the body that interfere with the functioning of certain antibiotics. The substance is part of antibacterial drugs. In combination with amoxicillin, it becomes the most effective.

The tool also contains auxiliary components necessary for shaping, stabilization, long-term storage of the drug:

• primrose sodium - a substance in the form of a powder, in the composition of medicines in tablet form it functions as a solvent, non-toxic, safe in minimal doses;
• MCC - dietary fiber, former, not absorbed in the body, excreted unchanged, harmless;
• silica - a crystalline powder of a natural nature, widely used in food production, improves the flowability of substances, is not absorbed in the intestine, is safe;
• crospovidone - an insoluble baking powder, does not have additional properties, is considered harmless;
• E 462 - a substance in the form of a colorless powder, increases the resistance of the tablet shell to external influences, is considered a harmful food supplement, negatively affects the condition of the mucous membranes of the digestive tract;
• E 463 - stabilizer in the form of a white granulate, in minimal doses does not have a negative effect;
• tween 80 - is present in the composition of drugs, acting as an emulsifier and a solvent of fats, allergenic, capable of causing severe intolerance reactions;
• talc is a mineral in the form of a crystalline powder, it is a food additive, conditionally harmless, and is banned in a number of countries, as it negatively affects the walls of the digestive tract;
• titanium dioxide - food bleach, an insoluble compound, is considered non-toxic, however, there is evidence of a possible negative effect on the state of the respiratory organs;
• E 1505 - citric acid ester, solvent, harmless food supplement.

Given the possibility of undesirable side effects in the process of using the medicine, before starting treatment it is important to discuss with the doctor the likelihood of developing an individual hypersensitivity reaction to both the main components of the drug and the controversial auxiliary elements of the composition.

Which group of antibiotics belongs

Amoxiclav 2x is a combination drug, beta-lactam antibiotic, which has low toxicity. This type of medicine was synthesized by English scientists at the beginning of the last century. All drugs of the beta-lactam group are similar in structure, mode of action and frequency of side effects. At present, they occupy a leading place among antibiotics for prescribing in the treatment of most diseases of an infectious nature.

Pharmacological action, pharmacodynamics and pharmacokinetics

The main active components of the drug are rapidly absorbed after ingestion. It is better to take it during the meal. The drug has a useful property to accumulate in organs and tissues. Its content in them increases in a short time. Sixty minutes after ingestion, Amoxiclav is found in high concentrations in the blood. It does not enter the meninges, therefore, does not adversely affect the functioning of the nervous system.

Due to the optimal combination of active ingredients, the drug is able to quickly stop the reproduction and growth of different types of microbes. The tool prevents the formation of plasmolemm of bacterial cells, which leads to their complete destruction.

In what cases is "Amoxiclav" 875 mg + 125 mg

Amoxiclav tablets 875 mg + 125 mg are used in the treatment of bacterial infections of the respiratory system, kidneys and genitourinary system, skin and gastrointestinal tract.

The drug is prescribed if it is diagnosed:

• infectious damage to the bronchi;
• middle ear inflammation;
• sinusitis;
• angina;
• tonsillitis;
• pulmonary infections;
• secondary skin infection with atopic dermatitis;
• inflammatory diseases of the pelvic organs;
• infectious lesions of the digestive system;
• the inflammatory process that arose due to improper dental treatment;
• infectious bone lesions.

The medication is used in gynecology and obstetric practice, as well as in the treatment of pathologies of the biliary tract.

Instructions for use and dosage for children and adults

Therapy will give quick results and will not harm if the drug is prescribed by a doctor, taking into account the patient's history and the possibility of an intolerance reaction.

The dose of the drug is calculated taking into account age, body weight and concomitant chronic diseases.

It is recommended that adults take Amoxiclav in a dosage of 500 + 125 mg up to three times a day. If the disease is severely launched and proceeds severely, an increase in dose is permissible. The duration of the course is determined by the doctor.

In the treatment of infectious diseases in young children, the drug is used in the form of a powder for diluting a suspension. The duration of the course and the amount of medicine for one dose is calculated by the doctor.

During pregnancy and lactation

Amoxiclav can be prescribed to women during gestation:

• if the infection is severe,
• if complications are possible,
• if the patient suffers from chronic diseases.

According to clinical studies conducted by Israeli doctors, the drug does not have a negative effect on the condition and development of the fetus, does not complicate the course of pregnancy.

The doctor can adjust the dose for the expectant mother to reduce in order to minimize the risks.

Drug interaction

If there is a need to use Amoxiclav antibiotic in treatment while taking other drugs, you need to carefully study the instructions for the use of medicines, since there are restrictions regarding the simultaneous use of certain drugs.

1. The combined use of Amoxiclav and such drugs for the treatment of alcohol dependence, as Antabus, Lidevin, Teturam, is contraindicated.
2. They take an antibiotic with caution against the background of the use of blood thinners in the treatment - Klivarina, Fraksiparina, Heparina.
3. The combined administration of Amoxiclav with antitumor agents, such as Zeksat, Emteksat, provokes an increase in their toxic effects on the body.
4. If the antibiotic is used in conjunction with diuretic drugs, the anti-inflammatory Butadion, the saturation of amoxicillin in the tissues increases.
5. When taking Amoxiclav against the background of using COCs to prevent unwanted pregnancy, it is necessary to additionally use barrier methods of contraception, since an antibiotic significantly reduces the effectiveness of birth control pills.
6. The antimicrobial drug is not taken together with Clarithromycin, Azithromycin, Roxithromycin, and Oletetrin, Kolbiocin, Tetracycline and Sulfadimethoxin, since in this case the effectiveness of Amoxiclav decreases.

All the nuances related to drug compatibility should be discussed with your doctor so that there are no negative effects during the treatment period.

Can I drink alcohol while taking the drug

The instructions for use of "Amoxiclav" indicate that the drug is not recommended for use with alcohol.

This combination is capable of:

• cause toxic liver damage;
• reduce the concentration of antibiotic components in the blood;
• provoke the appearance of migraine;
• cause a sharp decrease in blood pressure;
• provoke failures in the digestive tract.

The antibiotic will finally leave the body 36 hours after the last dose. This factor should be considered when planning leisure activities.

Contraindications, side effects and overdose

It is contraindicated to take Amoxiclav in the following cases:

• a previously fixed allergy to antibiotics of the penicillin series;
• inflammatory liver diseases;
• pathological process, accompanied by a lack of access to bile in the intestine.

According to doctors, Amoxiclav is better tolerated than drugs with unprotected amoxicillin.

However, unwanted side effects may occur:

• itchy dermatoses;
• violation of the integrity of the mucous membranes of the digestive tract;
• increased gas formation;
• diarrhea;
• loss of appetite;
• impaired liver function;
• thrush;
• increased anxiety;
• insomnia;
• migraine;
• dizziness.

If, for some reason, the recommended dose of the drug has been exceeded, abdominal pain, nausea, diarrhea, cephalgic syndrome, skin reactions occur.

Antibiotic Analogs

In pharmacies, you can find many substitutes for Amoxiclav, the active substance of which is amoxicillin.

Many Russian analogues are cheaper than the original drug. However, in their composition, amoxicillin is not supplemented with clavulanic acid, therefore the effectiveness of such agents is reduced.

The following medicines can completely replace Amoxiclav:

• Ecoclav (Russia);
• Amovikomb (China);
• Amoksiklav Kviktab (Slovenia, Switzerland);
• Arlet (Russia).

Analogs containing only amoxicillin as an active substance:

• Amoxicillin (China, Switzerland, Russia);
• Amosin (Russia);
• Ecobol (Russia);
• "Grunamox" (Germany).

If you need to replace the remedy recommended by the doctor with a similar one, you must re-contact a specialist for advice on choosing a dosage and excluding negative reactions of the body.